Synthesis, fabrication and properties research of CS-mPEG-AN nanocomposite. Issue 1 (11th June 2022)

• Record Type: Journal Article
• Authors: Wang, KangRui; Tang, Hong; Chen, Hongjie; Huang, Xiaorong; Fang, Ying; Men, Rongrong; Gao, Jie; Wang, Yue; Wang, Yang; Huang, ChengHong
• Is Part Of: Ferroelectrics. Volume 593:Issue 1(2022)
• Page Start: 37
• Page End: 50
• Publication Date: 2022-06-11
• Subjects: Chitosan -- 3-(9-Anthryl)acrolein -- carbon nanotubes -- PTX; Ferroelectricity -- Periodicals; Ferroelectric crystals -- Periodicals; 537
• DOI: 10.1080/00150193.2022.2076450
• Languages: English
• ISSNs: 0015-0193

Abstract

Abstract: A novel nanocomposite based on 3-(9-Anthryl)acrolein (AN) grafted onto mPEG-OOH carboxlyated Chitosan (CS-mPEG-AN) was prepared. The composites were further characterized by ultraviolet (UV), fluorescent spectrum, X-ray diffraction (XRD) and nuclear magnetic resonance (NMR). It has been demonstrated that the composite formed by ester bond and imine linkages. The powder of CS-mPEG-AN exhibit regular ellipsoid shapes. Fluorescent effect of the composite can be quenched by carbon nanotubes (CNTs) with concentration dependence. Nanoparticles of CS-mPEG-AN obtained by direct drying takes cubic shapes with SEM observation. The drug encapsulation and loading efficiency for paclitaxel (PTX) will up to 67.2% and 44.8% by 1:2 feed ratio of CS-mPEG-AN/PTX. In vitro drug release of PTX from the CS-mPEG-AN take 47.0% in acid (pH 5.0) and 27% in basic (pH 7.4) environments. The proposed CS-mPEG-AN composite and nanoparticles have the potential for application in the field of photoelectron transfer and drug delivery.