Relevance of circulating MiRNA-21 and MiRNA-181 in prediction of glioblastoma multiforme prognosis. (4th July 2022)

• Record Type: Journal Article
• Authors: Labib, Esraa M.; Ezz El Arab, Lobna R.; Ghanem, Hala M.; Hassan, Rasha E.; Swellam, Menha
• Is Part Of: Archives of physiology and biochemistry. Volume 128:Number 4(2022)
• Page Start: 924
• Page End: 929
• Publication Date: 2022-07-04
• Subjects: MiRNA -- Glioblastoma multiforme -- prediction -- prognosis -- response; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2020.1739716
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Background: Authors aimed to investigate the clinical role of miR-21 and miR-181 among glioblastoma multiforme (GBM) patients. Materials and methods: Expression for both miRs were detected in blood samples from newly diagnosed twenty GBM patients before and after treatment along with 20 healthy individuals using QPCR technology. Results: MiR-21 reported increase expression while miR-181 reported decreased expression in GBM patients. Expression of miR-21 was up-regulated in GBM patients older than 60 years and frontal mass with tumor size > 5 cm while miR-181 expression was down-regulated among them. Worse PFS and OS reported increase in miR-21 expression and decrease in miR-181 expression. Conclusion: Detection of miR-21 and miR-181 expression levels may be a potential diagnostic and predictors for GBM prognosis.