Isolation and Biological Evaluation of Prenylated Flavonoids from Maclura pomifera. (14th January 2018)

• Record Type: Journal Article
• Authors: Orazbekov, Yerkebulan; Ibrahim, Mohamed A.; Mombekov, Serjan; Srivedavyasasri, Radhakrishnan; Datkhayev, Ubaidilla; Makhatov, Bauyrzhan; Chaurasiya, Narayan D.; Tekwani, Babu L.; Ross, Samir A.
• Other Names: Zarrelli Armando Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2018(2018)
• Publication Date: 2018-01-14
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2018/1370368
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Phytochemical analysis of the ethanolic extract of Maclura pomifera fruits yielded four new compounds (I –IV ) along with eleven known compounds (V –XV ). The crude extract exhibited significant activity towards cannabinoid receptors (CB1: 103.4% displacement; CB2: 68.8% displacement) and possibly allosteric interaction with δ and μ opioid receptors (−49.7 and −53.8% displacement, resp.). Compound I was found to be possibly allosteric for κ and μ opioid receptors (−88.4 and −27.2% displacement, resp.) and showed moderate activity (60.5% displacement) towards CB1 receptor. Compound II exhibited moderate activity towards cannabinoid receptors CB1 and CB2 (47.9 and 42.3% displacement, resp.). The known compounds (V –VIII ) exhibited prominent activity towards cannabinoid receptors: pomiferin (V ) (IC50 of 2.110 and 1.318 μ M for CB1 and CB2, resp.), auriculasin (VI ) (IC50 of 8.923 μ M for CB1), warangalone (VII ) (IC50 of 1.670 and 4.438 μ M for CB1 and CB2, resp.), and osajin (VIII ) (IC50 of 3.859 and 7.646 μ M for CB1 and CB2, resp.). The isolated compounds were also tested for inhibition of human monoamine oxidase-A and monoamine oxidase-B enzymes activities, where all the tested compounds showed fewer inhibitory effects on MAO-A compared to MAO-B activities: auriculasin (VI ) (IC50 of 1.91 and 45.98 μ M for MAO-B and MAO-A, resp.).