Therapeutic Effects of Kangzhi Syrup in a Guinea Pig Model of Ovalbumin-Induced Cough Variant Asthma. (23rd May 2018)

• Record Type: Journal Article
• Authors: Wang, Youpeng; Zhu, Pengyu; Tan, Jiejun; Liu, Zhiwei; Qu, Wanying; Liu, Lujia; Li, Zhijun
• Other Names: Xu Junji Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2018(2018)
• Publication Date: 2018-05-23
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2018/5867835
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Purpose . This study aimed to investigate the possible effects and underlying mechanisms of Kangzhi syrup on ovalbumin- (OVA-) induced cough variant asthma (CVA) in guinea pigs. Methods . All 48 guinea pigs were randomly assigned to four experimental groups: normal, OVA model with or without Kangzhi syrup (OVA and OVA + KZ), and OVA with Dexamethasone (OVA + DM). After sensitizing the guinea pigs, a cough challenge was performed by the inhalation of capsaicin. The antitussive effect, inflammatory cells, cytokines in bronchoalveolar lavage fluid (BALF) and lung tissue, and morphological changes were examined. Results . Compared with model group, Kangzhi syrup effectively exerted an antitussive effect (p < 0.0 001 ) and reduced the pneumonic anaphylacticitis by inhibiting the infiltration of total inflammatory cells (p < 0.0 001 ) and reducing the percentage of eosinophil in BALF (p < 0.0 001 ). Moreover, evidence from morphological studies also demonstrated that Kangzhi syrup inhibited the infiltration of inflammatory cells and ameliorated the structure changes. NF- κ B and TGF- β 1 expression were attenuated in the OVA + KZ group versus the OVA group (p < 0.0 001 ). Additionally, a semiquantitative analysis of TGF- β 1 expression also demonstrated that the Kangzhi syrup attenuated this profibrogenic growth factor (p < 0.0 01 ). Conclusions . The results demonstrated that Kangzhi syrup exerted a considerable antitussive effect in CVA animal model, which depended on its marked impact on the anti-anaphylactic inflammation. Additionally, it could ameliorate the airway remodeling by inhibiting NF- κ B and TGF- β 1 signal pathway.