New‐onset fulminant type 1 diabetes after severe acute respiratory syndrome coronavirus 2 vaccination: A case report. Issue 7 (25th February 2022)

• Record Type: Journal Article
• Authors: Sasaki, Keyaki; Morioka, Tomoaki; Okada, Natsumi; Natsuki, Yuka; Kakutani, Yoshinori; Ochi, Akinobu; Yamazaki, Yuko; Shoji, Tetsuo; Ohmura, Takashi; Emoto, Masanori
• Is Part Of: Journal of diabetes investigation. Volume 13:Issue 7(2022)
• Page Start: 1286
• Page End: 1289
• Publication Date: 2022-02-25
• Subjects: Fulminant type 1 diabetes -- Severe acute respiratory syndrome coronavirus 2 -- Vaccination; Diabetes -- Periodicals; Diabetes -- Research -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1111/jdi.13771
• Languages: English
• ISSNs: 2040-1116

Abstract

Abstract: Fulminant type 1 diabetes is characterized by a rapid progression of insulin deficiency triggered by viral infection. Here, we report a case of a 45‐year‐old Japanese woman with fulminant type 1 diabetes that developed 8 days after receiving messenger ribonucleic acid vaccine against severe acute respiratory syndrome coronavirus 2. She had been healthy and had no symptoms suggestive of viral infection before the vaccination. Laboratory tests showed exhaustion of insulin secretion and negative results for islet autoantibodies. Human leukocyte antigen genotype analysis showed the DRB1*04:05 and DQB1*04:01 alleles. This is the first case report of new‐onset fulminant type 1 diabetes after severe acute respiratory syndrome coronavirus 2 vaccination, and suggests that a severe acute respiratory syndrome coronavirus 2 vaccine might trigger the onset of fulminant type 1 diabetes in susceptible individuals. However, a causal relationship remains to be identified, and further studies are required to determine the incidence of such cases. Abstract : We report a case of a 45‐year‐old Japanese woman with new‐onset fulminant type 1 diabetes after severe acute respiratory syndrome coronavirus 2 vaccination. This case suggests that severe acute respiratory syndrome coronavirus 2 vaccination might be a trigger for the development of fulminant type 1 diabetes in genetically susceptible individuals. Further studies are required to determine the incidence of fulminant type 1 diabetes associated with severe acute respiratory syndrome coronavirus 2 vaccination and the causality.