Paramagnetic ultrasmall Ho2O3 and Tm2O3 nanoparticles: characterization of r2 values and in vivo T2 MR images at a 3.0 T MR field. Issue 14 (16th June 2022)

• Record Type: Journal Article
• Authors: Liu, Shuwen; Tegafaw, Tirusew; Yue, Huan; Ho, Son Long; Kim, Soyeon; Park, Ji Ae; Baek, Ahrum; Ahmad, Mohammad Yaseen; Yang, So Hyeon; Hwang, Dong Wook; Kim, Seungho; Ali Al Saidi, Abdullah Khamis; Zhao, Dejun; Liu, Ying; Nam, Sung-Wook; Chae, Kwon Seok; Chang, Yongmin; Lee, Gang Ho
• Is Part Of: Materials advances. Volume 3:Issue 14(2022)
• Page Start: 5857
• Page End: 5870
• Publication Date: 2022-06-16
• Subjects: 620.11
• DOI: 10.1039/d2ma00322h
• Languages: English
• ISSNs: 2633-5409

Abstract

Abstract : Paramagnetic ultrasmall Ho2 O3 and Tm2 O3 nanoparticles grafted with various hydrophilic and biocompatible ligands as a new class of efficient T 2 MRI contrast agents were investigated in this study. Abstract : Paramagnetic ultrasmall Ho2 O3 and Tm2 O3 nanoparticles ( d avg = ∼2.1 nm) grafted with various hydrophilic and biocompatible ligands such as poly(ethylene glycol) diacid ( M n = 250 and 600 amu) and polyacrylic acid ( M w = 1800 amu) were synthesized via a one-pot polyol method. Appreciable transverse ( r 2 ) and negligible longitudinal ( r 1 ) water proton spin relaxivity values were observed for all nanoparticle samples. The r 2 values increased with increasing nanoparticle magnetic moment and decreased with increasing ligand size. Owing to the aforementioned r 1 and r 2 values, the nanoparticle samples exhibited appreciable negative contrast enhancements in in vivo T 2 magnetic resonance (MR) images at a 3.0 T MR field after intravenous injection, demonstrating their potential as efficient T 2 MRI contrast agents.