Catechol-modified chitosan hydrogel containing PLGA microspheres loaded with triclosan and chlorhexidine: a sustained-release antibacterial system for urinary catheters. (28th May 2022)

• Record Type: Journal Article
• Authors: Lin, Chengxiong; Huang, Zhengyu; Wu, Tingting; Xu, Weikang; Zhao, Ruifang; Zhou, Xinting; Xu, Zhibiao
• Is Part Of: Pharmaceutical development and technology. Volume 27:Number 5(2022)
• Page Start: 545
• Page End: 553
• Publication Date: 2022-05-28
• Subjects: Urinary catheters -- antibacterial coating -- microsphere -- chitosan -- CAUTI; Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.1080/10837450.2022.2086571
• Languages: English
• ISSNs: 1083-7450

Abstract

Abstract: Blockage and infection are common in hospitals, especially with long-term indwelling catheters, due to bacterial adhesion, colonization, and other reasons. A drug-sustained-release antibacterial coating for urinary catheters was described in this paper. Chlorhexidine (CHX) and triclosan (TCS) were encapsulated in poly(lactic-co-glycolic acid) microspheres and mixed with a modified chitosan hydrogel deposited on the surface of silicone rubber. The results showed that drugs can be released continuously more than 35 days. Catechol-modified chitosan (Chi-C) hydrogel was successful synthesized according to FT-IR and UV spectrophotometry, as well as 1 H NMR. Furthermore, the coating with CHX and TCS presented stable antibacterial ability compared to the other groups. The results of CCK-8 revealed that the coating was cytotoxic-free and had a wide range of applications. The findings could provide a new drug sustained-release system and hydrogel-microsphere assembly for urinary catheters. Highlights: The microspheres presented a sustained release more than 40 days with a remarkable initial burst release. The microspheres/catechol-modified chitosan (Chi-C)/silicon rubber system emerged stable binding ability in liquid environment more than 14 days. The Chi-C/chlorhexidine (CHX)+triclosan (TCS) microspheres system presented better antimicrobial property for entire experiment period. The coated samples showed no significant difference for relative growth rate (RGR) compared to different groups. Graphical Abstract: UF0001