The Effect of Chunghyul-Dan on Hyperventilation-Induced Carbon Dioxide Reactivity of the Middle Cerebral Artery in Normal Subjects: A Dose-Dependent Study. (20th April 2017)

• Record Type: Journal Article
• Authors: Jin, Chul; Moon, Sang-Kwan; Cho, Seung-Yeon; Park, Seong-Uk; Jung, Woo-Sang; Park, Jung-Mi; Ko, Chang-Nam; Cho, Ki-Ho; Kwon, Seungwon
• Other Names: Ohta Yoshiji Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2017(2017)
• Publication Date: 2017-04-20
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2017/4567217
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Background . This study was conducted to show the prompt effect of chunghyul-dan (CHD) on cerebral hemodynamics in order to provide evidence for its use in stroke prevention. Methods . Hyperventilation-induced CO2 reactivity of the middle cerebral artery was measured in 12 healthy male volunteers (mean age: 26.3 ± 1.1 years) using transcranial Doppler sonography. All subjects were examined before and for 3 hours after administration, with an interval of 1 week between measurements. Results . Compared to baseline, the CO2 reactivity of the middle cerebral artery increased significantly at 2 and 3 hours after the administration of CHD (600 mg and 1200 mg). The mean blood pressure and heart rate did not vary from the baseline values in all groups. Conclusion . These data suggest that CHD administration (especially 600 mg) immediately improves cerebral blood flow.