Reassignment of crispatene, isolation and chemical characterization of stachydrine, isolated from the marine mollusk Elysia crispata. Issue 15 (1st August 2022)

• Record Type: Journal Article
• Authors: Arrieche, Dioni; Ugarte, Alejandra; Salazar, Franklin; Villamizar, José E.; Rivero, Nelsy; Caballer, Manuel; Llovera, Ligia; Montañez, José; Taborga, Lautaro; Quintero, Alberto
• Is Part Of: Natural product research. Volume 36:Issue 15(2022)
• Page Start: 4013
• Page End: 4016
• Publication Date: 2022-08-01
• Subjects: Gastropod -- Sacoglossa -- Elysia crispata -- polypropionates -- γ-pyrone; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1895147
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The molluscan genus Elysia Risso, 1818 (Sacoglossa) is composed of shell-less herbivore sea slugs. From these marine organisms, polyketides such as polypropynates have been isolated and showed cytotoxic, antibiotic, and antifungal, and antiviral properties. In this work, we reported the isolation, and structure elucidation of two compounds isolated from marine mollusk E. crispata. Both compounds isolated, crispatene (1) and stachydrine (2), were purified by HPLC. The chemical structure of compound (1) was reassigned through 1D and 2D NMR experiments and high-resolution electrospray ionization mass spectrometry (HRESIMS). On the other hand, this is the first time that compound (2) has been found in this species of mollusk or the marine environment, previously, (2) has only been found in terrestrial plants or bacteria in symbiosis with plants. Graphical Abstract: UF0001