Synergistic Uric Acid-Lowering Effects of the Combination of Chrysanthemum indicum Linne Flower and Cinnamomum cassia (L.) J. Persl Bark Extracts. (9th July 2017)

• Record Type: Journal Article
• Authors: Lee, Young-Sil; Son, Eunjung; Kim, Seung-Hyung; Lee, Yun Mi; Kim, Ohn Soon; Kim, Dong-Seon
• Other Names: Hunyadi Attila Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2017(2017)
• Publication Date: 2017-07-09
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2017/9764843
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (L.) J. Persl bark (CB) extracts have served as the main ingredients in several prescriptions designed to treat hyperuricemia and gout in traditional Chinese and Korean medicine. However, little is known about the combination effects of a CF and CB (CC) mixture on hyperuricemia. In our study, we investigated the antihyperuricemic effects of CC mixture and the mechanisms underlying these effects in normal and potassium oxonate- (PO-) induced hyperuricemic rats. The CC mixture significantly decreased uric acid levels in normal and PO-induced hyperuricemic rats and showed the enhanced hypouricemic effect compared to CF or CB alone. Furthermore, the CC mixture increased renal uric acid excretion in PO-induced hyperuricemic rat. We found that CC mixture and its major components, chlorogenic acid, 3, 4-dicaffeoylquinic acid (isochlorogenic acid), coumarin, cinnamaldehyde, trans -cinnamic acid, and o -methoxycinnamaldehyde, inhibit the activity of xanthine oxidase (XOD) in vitro. The CC mixture exerts antihyperuricemic effects accompanied partially by XOD activity inhibition. Therefore, the CC mixture may have potential as a treatment for hyperuricemia and gout.