Components of Goutengsan in Rat Plasma by Microdialysis Sampling and Its Protection on Aβ1–42-Induced PC12 Cells Injury. (2nd March 2017)

• Record Type: Journal Article
• Authors: Huang, Hou-Cai; Wang, Chun-Fei; Gu, Jun-Fei; Chen, Juan; Hou, Xue-Feng; Zhong, Rong-Ling; Xia, Zhi; Zhao, Di; Yang, Nan; Wang, Jing; Tan, Xiao-Bin; Jia, Xiao-Bin; Di, Liu-Qing; Dong, Zi-Bo; Feng, Liang
• Other Names: Hugel Helmut Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2017(2017)
• Publication Date: 2017-03-02
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2017/7593027
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Goutengsan, a Chinese herbal formula, potential protection on Alzheimer's disease (AD) has been less reported. In current study, we investigated the protection of Goutengsan on A β 1–42 -induced pheochromocytoma-derived cells (PC12). Furthermore, the components from Goutengsan in rat plasma were identified by microdialysis (MD) for in vivo sampling. Meanwhile, the protection of components identified was also verified. At last, we found that Goutengsan has a potential protective effect on A β 1–42 -induced PC12 cells via reducing cells damage and increasing cells vitality as well as six components (pachymic acid, liquiritin, rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxeine) which may be effective components. This study helps to understand the treatment of Goutengsan for AD and would facilitate the clinical and further studies for this formula.