Three new polyketide derivatives of the endophytic fungus Aspergillus cristatus 2H1. Issue 8 (3rd August 2022)

• Record Type: Journal Article
• Authors: Wu, Xue-Ming; Dai, Guan-Cheng; Zhou, Bei-Bei; Chen, Yong; Tan, Ren-Xiang
• Is Part Of: Journal of Asian natural products research. Volume 24:Issue 8(2022)
• Page Start: 722
• Page End: 730
• Publication Date: 2022-08-03
• Subjects: Aspergillus cristatus -- polyketide derivatives -- antibacterial activity -- antitumoral activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2021.1972982
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Three new polyketide derivatives, 2-ethoxycarbonyl-endocrocin (1 ), 6-methoxy-2-ethoxycarbonyl-endocrocin (2 ) and pannorin C (3 ), along with sixteen known compounds (4–19 ) were isolated from a plant endophytic fungus Aspergillus cristatus 2H1. Their structures were elucidated by 1D/2D NMR and HR-ESI-MS data analysis. Compound 3 showed weak antibacterial activity against Staphylococcus aureus (MIC 20 μg/ml). Compounds 14 and 15 showed effective cytotoxicity on human melanoma A375 cells (IC50 4.13 μM for 14, 3.39 μM for 15 ). Graphical Abstract: UF0001