New Urea and Thiourea Derivatives of Piperazine Doped with Febuxostat: Synthesis and Evaluation of Anti-TMV and Antimicrobial Activities. (24th October 2013)

• Record Type: Journal Article
• Authors: Krishna Reddy, Reddivari Chenna; Rasheed, Syed; Subba Rao, Devineni; Adam, Shaik; Venkata Rami Reddy, Yellala; Raju, Chamarthi Naga
• Other Names: Appelt H. R. Academic Editor.; Aragoncillo C. Academic Editor.; Elmegeed G. A. Academic Editor.; Miyabe H. Academic Editor.; Pellissier H. Academic Editor.
• Is Part Of: TheScientificWorldjournal. Volume 2013(2013)
• Publication Date: 2013-10-24
• Subjects: Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1155/2013/682603
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : A series of new 4-(5-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-2-carbonyl)-N-(substituted phenyl)piperazine-1-carboxamides 8(a–e) /carbothioamides 8(f–j) were accomplished for biological interest by the simple addition of active functionalized arylisocyanates 7(a–e) /arylisothiocyanates 7(f–j) with 2-isobutoxy-5-(4-methyl-2-(piperazine-1-carbonyl)thiazol-5-yl)benzonitrile (4) . Compound 4 was synthesized in high yields (94%) by the condensation reaction of febuxostat (1) with piperazine using a selective reagent such as propylphosphonic anhydride (T3 P). Antiviral activity against Tobacco mosaic virus (TMV) and antimicrobial activity of the synthesized compounds were evaluated. Biological data revealed that 4-nitrophenyl substituted urea 8d, and 3-bromophenyl substituted thiourea 8f exhibited promising antiviral activities. Moreover, 4-fluorophenyl substituted urea 8a, 4-nitrophenyl substituted urea 8d, 3-bromophenyl substituted thiourea 8f, and 2, 4-dichlorophenyl substituted thiourea 8j exhibited potent antimicrobial activity.