Synthesis of CoFe2O4/MoO2 dumbbell-shaped nanoparticles with enhanced AMF/NIR induced drug delivery for liver cancer treatment. Issue 19 (1st October 2022)

• Record Type: Journal Article
• Authors: Mao, Huarong; Chang, Qimeng; Zhang, Ziping; Feng, Jinfeng; Zhou, Xiang; Hu, Zhiqiu
• Is Part Of: Ceramics international. Volume 48:Issue 19(2022)Part A
• Page Start: 28640
• Page End: 28648
• Publication Date: 2022-10-01
• Subjects: Dumbbell-shaped nanoparticles -- Alternating magnetic field (AMF) -- Near infrared (NIR) -- Drug delivery -- Doxorubicin (DOX); Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2022.06.178
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: Dumbbell-shaped CoFe2 O4 /MoO2 nanoparticles with a high surface area were synthesized by a wet-chemistry method. The nanoparticle surface was further modified with poly(methacrylic acid) (PMMA) to load doxorubicin (DOX), which was sealed within the composite with a phase change material of 1-tetradecanol (TD). Finally, the CoFe2 O4 /MoO2 /PMMA/DOX/TD composite was prepared. The DOX release was induced by external magnetic/photothermal effects, with CoFe2 O4 as the magnetic material and MoO2 as the photothermal material. The impacts of alternating magnetic field (AMF) frequency and near-infrared (NIR) irradiation power on the thermal effects and DOX release were investigated. Finally, the cytotoxicity of human liver tumor cells (hepatocellular carcinoma) with CoFe2 O4 /MoO2 /PMMA/DOX/TD was studied under different conditions (AMF, NIR, and their combination). The results indicated that AMF/NIR combined thermal effects brought the maximum killing rate of the tumor cells. This research proposed a low-cost synthesis of hybrid thermal materials for AMF/NIR-induced DOX delivery for liver cancer treatment.