Gene Mutation and Its Association with Clinicopathological Features in Young Patients with Non-Small-Cell Lung Cancer. (5th July 2022)

• Record Type: Journal Article
• Authors: Kong, Wencui; Yu, Zongyang; Wang, Wenwu; Yang, Jingrong; Wang, Jingfang; Zhao, Zhongquan
• Other Names: Li Weiguo Academic Editor.
• Is Part Of: Emergency medicine international. Volume 2022(2022)
• Publication Date: 2022-07-05
• Subjects: Emergency medicine -- Periodicals; Medical emergencies -- Periodicals; 616.025
• DOI: 10.1155/2022/6333282
• Languages: English
• ISSNs: 2090-2840

Abstract

Abstract : Background . We investigated the correlation between genetic mutations and clinical-pathological features in young patients with NSCLC. Methods . Clinicopathologic information of 102 young NSCLC patients was collected. Direct ctDNA sequencing of a portion of these patients was performed. The correlation between EGFR mutation and ALK fusions with clinicopathologic parameters was analyzed. Results . In young NSCLC patients, adenocarcinoma is the major histology (86.9%), and the misdiagnosis rate was as high as 45.7%. EGFR gene mutation was found in 13 patients (31.7%) and common mutations were with EGFR19del mutation (7 cases, 17.1%) and EGFR21L858R mutation (4 patients, 9.7%). EGFR mutation was constantly found in adenocarcinoma and male gender, and ever smokers (100%, P < 0.05 ). Furthermore, ALK fusions were found in 7 patients (31.8%), which include EML-4-ALK fusions; there was a trend that ALK fusions were associated with adenocarcinoma and female gender. However, there was no significant difference in overall survival between patients with or without gene mutations. Conclusions . EGFR mutation and ALK fusions are related to histology, gender, and smoke exposure in young NSCLC patients, and may be effective predictive factors.