The diagnostic accuracy of methylation markers in urine for the detection of bladder cancer: a systematic review. (25th April 2018)

• Record Type: Journal Article
• Authors: Bosschieter, Judith; Lutz, Catrin; Segerink, Loes I; Vis, André N; Zwarthoff, Ellen C; A van Moorselaar, R Jeroen; van Rhijn, Bas WG; Heymans, Martijn W; Jansma, Elizabeth P; Steenbergen, Renske DM; Nieuwenhuijzen, Jakko A
• Is Part Of: Epigenomics. Volume 10:Number 5(2018)
• Page Start: 673
• Page End: 687
• Publication Date: 2018-04-25
• Subjects: biomarkers -- methylation -- molecular diagnostics -- neoplasms -- urinary bladder -- urine analysis; Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi-2017-0156
• Languages: English
• ISSNs: 1750-1911

Abstract

Aim: Several urinary hypermethylation-markers (hmDNA) have been described for bladder cancer (BC) detection, but none have been able to replace cystoscopy yet. We systematically reviewed and evaluated current literature on urinary hmDNA markers for BC diagnostics.Patients & methods: A systematic search of PubMed, EMBASE.com and The Cochrane Library up to February 2017 using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, was conducted.Results: A total of 30/42 studies included compared gene panels, with varying sensitivities (52–100%) and specificities (0–100%). Considerable heterogeneity across studies was observed and most was case–control studies.Conclusion: Reported diagnostic accuracy of urinary hmDNA for BC detection is highly variable and there is a lack of validation studies. Recent studies indicate that complementary markers are needed to allow for clinical implementation.