Evidence That Blunted CD4 T-Cell Responses Underlie Deficient Protective Antibody Responses to Influenza Vaccines in Repeatedly Vaccinated Human Subjects. (26th August 2019)

• Record Type: Journal Article
• Authors: Richards, Katherine A; Shannon, Ian; Treanor, John J; Yang, Hongmei; Nayak, Jennifer L; Sant, Andrea J
• Is Part Of: Journal of infectious diseases. Volume 222:Number 2(2020)
• Page Start: 273
• Page End: 277
• Publication Date: 2019-08-26
• Subjects: CD4 T cells -- cell-mediated immunity -- influenza vaccine -- influenza virus; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiz433
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Despite the benefits of yearly influenza vaccination, accumulating evidence suggests that diminished vaccine efficacy may be related to repeated vaccination. Although studied at the level of B-cell responses, CD4 T-cell responses have not yet been examined. In this study, we analyze CD4 T-cell responses to influenza vaccination in subjects who differ in their vaccine history. We find a striking disparity in their responses, with previously vaccinated subjects exhibiting significantly blunted CD4 T-cell responses and diminished antibody responses. These results suggest that limiting CD4 T-cell help mteaserrlie the diminished or altered antibody responses in repeatedly vaccinated subjects. Abstract : Antibody responses to influenza vaccines are often diminished in individuals who are repeatedly vaccinated. Here, we discovered that requisite CD4 T-cell responses are similarly reduced, suggesting that early events in vaccine-induced immunity are blunted in repeatedly vaccinated subjects.