The gut–brain axis in irritable bowel syndrome and inflammatory bowel disease. Issue 3 (March 2021)

• Record Type: Journal Article
• Authors: Ancona, Angela; Petito, Claudia; Iavarone, Irene; Petito, Valentina; Galasso, Linda; Leonetti, Alessia; Turchini, Laura; Belella, Daniela; Ferrarrese, Daniele; Addolorato, Giovanni; Armuzzi, Alessandro; Gasbarrini, Antonio; Scaldaferri, Franco
• Is Part Of: Digestive and liver disease. Volume 53:Issue 3(2021)
• Page Start: 298
• Page End: 305
• Publication Date: 2021-03
• Subjects: Gut–brain axis -- Gut inflammation -- IBD -- IBS -- Probiotics -- Psychobiotics; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2020.11.026
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: Research increasingly demonstrates the bidirectional communication between gut microbiota and the brain, enhancing the role of gut microbiota modulation in the treatment of central nervous system (CNS) disorders. The first five years of life are extremely important as it affects the development of gut microbiota, immune system and, consequently, the onset of psychometric alterations, particularly in genetically predisposed individuals. In this review, we focus on the link between specific microbial genera, gastrointestinal (GI) disorders, anxiety and depression and on the effects of different therapeutic strategies for mood disorders on gut microbiota.