Long non-coding RNA HAND2-AS1 inhibits gastric cancer progression by suppressing TCEAL7 expression via targeting miR-769–5p. Issue 2 (February 2021)

• Record Type: Journal Article
• Authors: Yu, Lan; Luan, Wei; Feng, Zongqi; Jia, Jianchao; Wu, Zhouying; Wang, Min; Li, Feng; Li, Zhiying
• Is Part Of: Digestive and liver disease. Volume 53:Issue 2(2021)
• Page Start: 238
• Page End: 244
• Publication Date: 2021-02
• Subjects: HAND2-AS1 -- miR-769–5p -- TCEAL7 -- Gastric cancer -- Competitive RNA; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2020.08.045
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: Increasing evidence showed that Heart and Neural Crest Derivatives Expressed 2 antisense RNA 1 (HAND2-AS1) was involved in the progression of several cancers, but its expression and function in gastric cancer (GC) was rarely reported. HAND2-AS1 expression in GC tissues and cells was detected at first. Cell function assays were performed to investigate the biological roles of HAND2-AS1 in GC cells. Moreover, the genes regulated by HAND2-AS1 in GC were investigated. Downregulation of HAND2-AS1 was found in GC tissues and cell lines. HAND2-AS1 overexpression inhibited GC cell proliferation, invasion, and arrested cell cycle at G0/G1 phase, whereas HADN2-AS1 knockdown significantly promoted cell proliferation and invasion. Bioinformatic analysis showed there is a potential HADN2-AS1/microRNA-769–5p (miR-769–5p)/transcription elongation factor A like 7 (TCEAL7) axis in GC. Luciferase activity reporter system was used to confirm this link. Taken together, our study showed that HAND2-AS1 exerts its tumor suppressive role in GC via regulating miR-769–5p/TCEAL7.