The Collaborative Ocular Tuberculosis Study (COTS) Consensus (CON) Group Meeting Proceedings. (30th September 2020)

• Record Type: Journal Article
• Authors: Agrawal, Rupesh; Testi, Ilaria; Mahajan, Sarakshi; Yuen, Yew Sen; Agarwal, Aniruddha; Rousselot, Andres; Raje, Dhananjay; Gunasekeran, Dinesh Visva; Kon, Onn Min; Barisani-Asenbauer, Talin; Kempen, John H.; Gupta, Amod; Jabs, Douglas A.; Smith, Justine R.; Bodaghi, Bahram; Zierhut, Manfred; DeSmet, Marc; Cluskey, Peter Mc; Agarwal, Mamta; Agarwal, Manisha; Aggarwal, Kanika; Agrawal, Mukesh; Al-Dhibi, Hassan; Androudi, Sofia; Asyari, Fatma; Balasundaram, Manohar Babu; Murthy, Kalpana Babu; Baglivo, Edoardo; Banker, Alay; Bansal, Reema; Basu, Soumyava; Behera, Digamber; Biswas, Jyotirmay; Carreño, Ester; Caspers, Laure; Chee, Soon Phaik; Chhabra, Romi; Cimino, Luca; del Rio, Luz Elena Concha; Cunningham, Emmett T.; Curi, Andrè Luiz Land; Das, Dipankar; Denisova, Ekaterina; Denniston, Alastair K; Errera, Marie-Hélène; Fonollosa, Alejandro; George, Amala; Goldstein, Debra A.; Crosier, Yan Guex; Gurbaxani, Avinash; Invernizzi, Alessandro; Isa, Hazlita M.; Md. Islam, Shah; Jones, Nicholas; Katoch, Deeksha; Khairallah, Moncef; Khosla, Amit; Kramer, Michal; Kumar, Amitabh; Kumar, Atul; Nora, Rina La Distia; Lee, Richard; Lowder, Careen; Luthra, Saurabh; Mahendradas, Padmamalini; Makhoul, Dorine; Mazumdar, Shahana; Mehta, Salil; Miserocchi, Elisabetta; Mochizuki, Manabu; Mohamed, Oli S.; Muccioli, Cristina; Munk, Marion R; Murthy, Somasheila; Narain, Shishir; Nascimento, Heloisa; Neri, Piergiorgio; Nguyen, Myhanh; Okada, Annabelle A.; Ozdal, Pinar; Palestine, Alan; Pichi, Francesco; Rathinam, S.R; Schlaen, Ariel; Sehgal, Shobha; Sen, H Nida; Sharma, Aman; Sharma, Kusum; Shoughy, Samir S.; Singh, Nirbhai; Singh, Ramandeep; Soheilian, Masoud; Sridharan, Sudharshan; Thorne, Jennifer E.; Tappeiner, Christoph; Teoh, Stephen; Tognon, Maria Sofia; Tugal-Tutkun, Ilknur; Tyagi, Mudit; Uy, Harvey; Santos, Daniel Vitor Vasconcelos; Valentincic, Natasa Vidovic; Westcott, Mark; Yanai, Ryoji; Alvarez, Bety Yanez; Zahedur, Rahman; Nguyen, Quan Dong; Pavesio, Carlos; Gupta, Vishali;
• Is Part Of: Ocular immunology and inflammation. Volume 28:Number 1(2020)
• Page Start: 85
• Page End: 95
• Publication Date: 2020-09-30
• Subjects: Antitubercular therapy -- choroiditis -- Collaborative Ocular Tuberculosis Study Consensus (COTS CON) -- consensus guidelines -- ocular tuberculosis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2020.1716025
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: An international, expert led consensus initiative was set up by the Collaborative Ocular Tuberculosis Study (COTS) group to develop systematic, evidence, and experience-based recommendations for the treatment of ocular TB using a modified Delphi technique process. In the first round of Delphi, the group identified clinical scenarios pertinent to ocular TB based on five clinical phenotypes (anterior uveitis, intermediate uveitis, choroiditis, retinal vasculitis, and panuveitis). Using an interactive online questionnaires, guided by background knowledge from published literature, 486 consensus statements for initiating ATT were generated and deliberated amongst 81 global uveitis experts. The median score of five was considered reaching consensus for initiating ATT. The median score of four was tabled for deliberation through Delphi round 2 in a face-to-face meeting. This report describes the methodology adopted and followed through the consensus process, which help elucidate the guidelines for initiating ATT in patients with choroidal TB.