CircadiOmics: circadian omic web portal. Issue Volume 50:Issue W1(2022) (3rd June 2022)

• Record Type: Journal Article
• Authors: Samad, Muntaha; Agostinelli, Forest; Sato, Tomoki; Shimaji, Kohei; Baldi, Pierre
• Is Part Of: Nucleic acids research. Volume 50:Issue W1(2022)
• Page Start: W183
• Page End: W190
• Publication Date: 2022-06-03
• Subjects: Nucleic acids -- Periodicals; Molecular biology -- Periodicals; 572.805
• DOI: 10.1093/nar/gkac419
• Languages: English
• ISSNs: 0305-1048

Abstract

Abstract: Circadian rhythms are a foundational aspect of biology. These rhythms are found at the molecular level in every cell of every living organism and they play a fundamental role in homeostasis and a variety of physiological processes. As a result, biomedical research of circadian rhythms continues to expand at a rapid pace. To support this research, CircadiOmics (http://circadiomics.igb.uci.edu/ ) is the largest annotated repository and analytic web server for high-throughput omic (e.g. transcriptomic, metabolomic, proteomic) circadian time series experimental data. CircadiOmics contains over 290 experiments and over 100 million individual measurements, across >20 unique tissues/organs, and 11 different species. Users are able to visualize and mine these datasets by deriving and comparing periodicity statistics for oscillating molecular species including: period, amplitude, phase, P -value and q -value. These statistics are obtained from BIO_CYCLE and JTK_CYCLE and are intuitively aggregated and displayed for comparison. CircadiOmics is the most up-to-date and cutting-edge web portal for searching and analyzing circadian omic data and is used by researchers around the world. Graphical Abstract: