Catalyst-free UV365-assisted synthesis of pyran annulated heterocyclic scaffolds and evaluation of their antibacterial activities. Issue 2 (17th January 2021)

• Record Type: Journal Article
• Authors: Dutta, Arup; Rahman, Noimur; Kumar, John Elisa; Rabha, Jintu; Phukan, Tridip; Nongkhlaw, Rishanlang
• Is Part Of: Synthetic communications. Volume 51:Issue 2(2021)
• Page Start: 263
• Page End: 278
• Publication Date: 2021-01-17
• Subjects: Antimicrobial activities -- catalyst-free -- Knoevenagel condensation -- pyran-based heterocycles -- UV-365 photo-irradiation; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2020.1825741
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: A convenient and eco-friendly, one-pot synthetic protocol for pharmaceutically important pyran-based heterocyclic compounds is repeated herein. The reactions were carried out at room temperature in a water–ethanol solvent mixture under direct irradiation of UV365 light source in the absence of photocatalyst. The merits of the present protocol include mild and catalyst-free reactions, green procedures, and high yields. The added advantage of this protocol is that it can be applied for large-scale synthesis of various pyran-based heterocyclic compounds without employing any expensive catalyst. Also, in vitro antibacterial screening of pyran derivative was investigated against both Gram-positive Bacillus cereus ( B. cereus ) and Gram-negative bacteria Escherichia coli ( E. coli ). Graphical Abstract: