Fabrication, characterization and in vitro release kinetics of tofacitinib-encapsulated polymeric nanoparticles: a promising implication in the treatment of rheumatoid arthritis. Issue 7 (3rd May 2021) - Bashir, Sajid
Abstract: Despite exhibiting remarkable efficacy for treatment of rheumatoid arthritis, clinical applicability of tofacitinib (TFC) is limited owing to its short plasma half-life. Therefore, this study was aimed to design a novel poly-(lactic-co-glycolic acid)-based nanoparticles to achieve sustained release as well as target-specific delivery of TFC. TFC-loaded-NPs exhibited 248 ± 14 nm size, −40 ± 4.3 mV zeta potential, and 60% entrapment efficiency. A biphasic release pattern which follow Higuchi model ( R 2 = 0.9825) and Fickian diffusion ( n < 0.5) has been perceived. Conclusively, we evidenced that TFC-PLGA-NPs could be a promising nanodelivery system to improve pharmacokinetic profile of TFC. Graphical Abstract: