An observational study demonstrating the adherence and ease of use of the injector device, RebiSmart®. (3rd May 2020)

• Record Type: Journal Article
• Authors: Vališ, Martin; Šarláková, Jana; Halúsková, Simona; Klímová, Blanka; Potužník, Pavel; Peterka, Marek; Kuča, Kamil; Štourač, Pavel; Mareš, Jan; Pavelek, Zbyšek
• Is Part Of: Expert opinion on drug delivery. Volume 17:Number 5(2020)
• Page Start: 719
• Page End: 724
• Publication Date: 2020-05-03
• Subjects: Multiple Sclerosis -- patients -- adherence -- treatment -- use -- RebiSmart; Drug delivery devices -- Periodicals; Drug delivery systems -- Periodicals; 615.605
• DOI: 10.1080/17425247.2020.1742694
• Languages: English
• ISSNs: 1742-5247

Abstract

ABSTRACT: Background: Adherence to Multiple Sclerosis (MS) treatment is considered one of the crucial factors for ensuring optimal clinical outcomes. Research has shown that the use of self-injector devices improves patient compliance with treatment. Therefore, the main purpose of this study is to evaluate the ease of use of RebiSmart® 2.0 in clinically isolated syndrome/relapsing-remitting MS patients during 12 months treatment period. Methods: A total number of 290 subjects entered into data collection; 249 (86%) of them completed the whole 12 months study period. The primary endpoints and the secondary endpoints were assessed by the User Study Questionnaire. Adherence data were retrieved from RebiSmart® 2.0 (Menu – Dose History) on the respective patient's visit. Outcome measures also included Expanded Disability Status Score, Kurtzke Functional Systems, and Modified Social Support Survey, Modified Social Support Survey-5. Results: This study demonstrated a very high proportion (>95%) of patients with a positive rating of the overall ease of use and the overall convenience of RebiSmart®. The proportion of patients with a positive rating of the ease of use by individual domains and the functions of RebiSmart® were also high (>80%). Conclusion: The findings demonstrate a very good perception of the usability of the device by patients overall and in its individual functions.