Treatment of Uveitis and Outcomes of Glaucoma Drainage Implant Surgery: A Meta-Analysis. (3rd July 2020)

• Record Type: Journal Article
• Authors: Chaku, Meenakshi; Bajwa, Asima; Lee, Jae K.; Netland, Peter A.
• Is Part Of: Ocular immunology and inflammation. Volume 28:Number 5(2020)
• Page Start: 833
• Page End: 838
• Publication Date: 2020-07-03
• Subjects: Glaucoma drainage implant -- glaucoma surgical outcomes -- immunomodulatory therapy -- meta-analysis -- uveitic glaucoma; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2019.1629602
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: We performed a meta-analysis to evaluate the effect of uveitis treatment on glaucoma drainage implant surgical outcomes. Methods: We included 16 articles in the meta-analysis. Two groups were defined based on medical therapy of uveitis: Group 1: poorly controlled uveitis, and Group 2: well-controlled uveitis including use of immunomodulatory medications. Results: The two groups were similar in comparisons of follow-up time, age, gender, and etiology of uveitis. Meta-analysis demonstrated significantly greater success in Group 2 (95.1%) compared to Group 1 (81.6%) at 1 year after glaucoma drainage implant surgery ( P = .001). The final success was significantly greater ( P 0.014) in group 2 compared with group 1 (86.1% and 74.3%, respectively). Conclusion: Surgical success was significantly higher in uveitic glaucoma patients treated with more intensive immunosuppressive therapy before and after glaucoma drainage implant surgery. The level of control of uveitis perioperatively appears to influence glaucoma drainage implant surgery outcomes.