Maternal Pyelonephritis as a Potential Cause of Perinatal Periventricular Venous Infarction in Term-Born Children. (August 2022)

• Record Type: Journal Article
• Authors: Ilves, Norman; Laugesaar, Rael; Rull, Kristiina; Metsvaht, Tuuli; Lintrop, Mare; Laan, Maris; Loorits, Dagmar; Kool, Pille; Ilves, Pilvi
• Is Part Of: Journal of child neurology. Volume 37:Number 8/9(2022)
• Page Start: 677
• Page End: 688
• Publication Date: 2022-08
• Subjects: perinatal stroke -- presumed stroke -- periventricular venous infarction -- maternal infection -- newborns; Nervous system -- Diseases -- Periodicals; 618.928
• DOI: 10.1177/08830738221109340
• Languages: English
• ISSNs: 0883-0738

Abstract

Introduction: The study was designed to assess the prevalence of pregnancy and delivery associated risk factors in children suffering from neonatal or presumed periventricular venous infarction.Methods: Antenatal records and pregnancy outcome data were retrospectively assessed in children with presumed periventricular venous infarction (n = 43, born ≥36 gestational weeks) or neonatal periventricular venous infarction (n = 86, born <36 gestational weeks) and compared to a matched control group (n = 2168, ≥36 gestational weeks) from a prospective study.Results: Children with presumed periventricular venous infarction had significantly more maternal bacterial infections compared to the control group (47% vs 20%, respectively, P < .001), whereas no difference was found compared to the neonatal periventricular venous infarction group (49%, P = .80). Mothers with bacterial infection in the presumed periventricular venous infarction group had significantly more often pyelonephritis compared to the control group (50% vs 3.4%, respectively, P < .001).Conclusions: Our data show an increased risk for developing periventricular venous infarction in the case of maternal bacterial infections, especially between gestational weeks 21 and 31.