Keeping the autophagy tempo. Issue 10 (3rd October 2019)

• Record Type: Journal Article
• Authors: Pastore, Nunzia; Ballabio, Andrea
• Is Part Of: Autophagy. Volume 15:Issue 10(2019)
• Page Start: 1854
• Page End: 1856
• Publication Date: 2019-10-03
• Subjects: Autophagy -- circadian rhythm -- gene oscillation -- NR1D1/REV-ERBα -- TFEB/TFE3; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2019.1645545
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: Most essential physiological functions in mammals show a 24-h rhythmic pattern, which includes sleep-wake, feeding-non-feeding cycles and energy metabolism. Recent studies indicate that macroautophagy/autophagy also displays a robust circadian rhythmicity following the daily feeding pattern in adult mammals. We discovered that MiT-TFE transcription factors TFEB and TFE3, master regulators of autophagy and lysosomal biogenesis, are activated in a circadian manner and drive the expression of NR1D1/REV-ERBα, a key component of the core clockwork, thus revealing a molecular link between the nutrient-driven circadian cycle and the light-induced molecular clock. The dynamic balance between TFEB and TFE3 activation and NR1D1 expression is responsible for the modulation and oscillation of autophagy and metabolism genes.