A bidirectional crosstalk between autophagy and TP53 determines the pace of aging. (2nd September 2020)
- Record Type:
- Journal Article
- Title:
- A bidirectional crosstalk between autophagy and TP53 determines the pace of aging. (2nd September 2020)
- Main Title:
- A bidirectional crosstalk between autophagy and TP53 determines the pace of aging
- Authors:
- Sica, Valentina
Kroemer, Guido - Abstract:
- ABSTRACT: When the orthologue of tumor suppressor protein p53 ( TP53), cep-1, is inactivated in Caenorhabditis elegans, the nematodes manifest an autophagy-dependent increase in lifespan. A recent paper by Yang et al . demonstrates that accelerated aging phenotype of autophagy-deficient mice can be reduced by the knockout (KO) of Trp53 . These findings point to a complex bidirectional crosstalk between autophagy and TP53 that has vast implications for the aging process.
- Is Part Of:
- Molecular & cellular oncology. Volume 7:Number 5(2020)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 7:Number 5(2020)
- Issue Display:
- Volume 7, Issue 5 (2020)
- Year:
- 2020
- Volume:
- 7
- Issue:
- 5
- Issue Sort Value:
- 2020-0007-0005-0000
- Page Start:
- Page End:
- Publication Date:
- 2020-09-02
- Subjects:
- Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2020.1769434 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 22949.xml