Designing and Testing of a Health-Economic Markov Model for Prevention and Treatment of Early Psychosis. (3rd May 2020)

• Record Type: Journal Article
• Authors: Wijnen, Ben F.M.; Thielen, Frederick W.; Konings, Steef; Feenstra, Talitha; Van Der Gaag, Mark; Veling, Wim; De Haan, Lieuwe; Ising, Helga; Hiligsmann, Mickaël; Evers, Silvia M.A.A.; Smit, Filip; Lokkerbol, Joran
• Is Part Of: Expert review of pharmacoeconomics & outcomes research. Volume 20:Number 3(2020)
• Page Start: 269
• Page End: 279
• Publication Date: 2020-05-03
• Subjects: Schizophrenia -- psychosis -- health economic modelling -- economic evaluation -- budget impact -- cost-effectiveness; Pharmacology -- Economic aspects -- Periodicals; 338.47615105
• DOI: 10.1080/14737167.2019.1632194
• Languages: English
• ISSNs: 1473-7167

Abstract

ABSTRACT: Background: This study aims to report on the design of a model to determine the cost-effectiveness of prevention and treatment of early psychosis (PsyMod) and to estimate ten-year cost-effectiveness and budget impact of interventions targeting individuals with ultra-high risk (UHR) of developing psychosis or with first episode psychosis (FEP). Methods: PsyMod was built in parallel with the development of a new standard of care for treatment of early psychosis in the Netherlands. PsyMod is a state-transition cohort simulation model and considers six health states, namely ultra-high risk of psychosis (UHR), FEP, post-FEP, no-UHR, recovery/remission, and death. Results are expressed as total healthcare costs, QALYs, incremental cost-effectiveness ratio (ICER), and budget impact. Results: PsyMod was used to extrapolate budget impact and cost-effectiveness of cognitive behavioural therapy for preventing FEP for individuals at UHR of psychosis (CBTuhr) compared to care as usual. CBTuhr resulted in a per-patient increase of 0.06 QALYs and a per patient cost reduction of €654 (dominant ICER) with a reduction in 5-year healthcare costs of €1, 002, 166. Conclusions: PsyMod can be used to examine cost-effectiveness and budget impact of interventions targeting prevention and treatment of FEP and is freely available for academic purposes upon request by the authors.