Potential of human induced pluripotent stem cells in studies of liver disease. Issue 1 (10th February 2015)

• Record Type: Journal Article
• Authors: Sampaziotis, Fotios; Segeritz, Charis‐Patricia; Vallier, Ludovic
• Is Part Of: Hepatology. Volume 62:Issue 1(2015:Jul.)
• Page Start: 303
• Page End: 311
• Publication Date: 2015-02-10
• Subjects: Heart -- Diseases -- Nursing -- Periodicals; Lungs -- Diseases -- Nursing -- Periodicals; Intensive care nursing -- Periodicals; Foie -- Maladies -- Périodiques; 616.362
• DOI: 10.1002/hep.27651
• Languages: English
• ISSNs: 0270-9139

Abstract

Abstract : Liver disease is a leading cause of death in the Western world. However, our insight into the underlying disease mechanisms and the development of novel therapeutic agents has been hindered by limited availability of primary tissue, intraspecies variability associated with the use of animal models, and reduced long‐term viability of isolated and diseased liver cells. The emergence of human induced pluripotent stem cells and differentiation protocols to generate hepatocyte‐like cells has opened the possibility of addressing these issues. Here, we discuss the recent progress and potential in the production of various cell types constituting the liver and their applications to model liver diseases and test drug toxicity in vitro . (Hepatology 2015;62:303‐311)