In vivo CRISPR screens reveal potent driver mutations in head and neck cancers. (3rd July 2020)
- Record Type:
- Journal Article
- Title:
- In vivo CRISPR screens reveal potent driver mutations in head and neck cancers. (3rd July 2020)
- Main Title:
- In vivo CRISPR screens reveal potent driver mutations in head and neck cancers
- Authors:
- Loganathan, Sampath Kumar
Schramek, Daniel - Abstract:
- ABSTRACT: We have recently tested the transforming potential of 484 'long-tail' genes, which are recurrently albeit infrequently mutated in head and neck cancers (HNSCC). We identified 15 novel tumor suppressors and our top hits converge on regulating the NOTCH signaling pathway. Therapeutic approaches activating NOTCH signaling could be a promising strategy to treat two-thirds of human HNSCC patients.
- Is Part Of:
- Molecular & cellular oncology. Volume 7:Number 4(2020)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 7:Number 4(2020)
- Issue Display:
- Volume 7, Issue 4 (2020)
- Year:
- 2020
- Volume:
- 7
- Issue:
- 4
- Issue Sort Value:
- 2020-0007-0004-0000
- Page Start:
- Page End:
- Publication Date:
- 2020-07-03
- Subjects:
- HNSCC -- Notch -- mouse models of cancer -- long-tail genes -- in vivo CRISPR
Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2020.1758541 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 22948.xml