Volunteer unrelated donor cell‐derived acute myeloid leukemia with RUNX1‐RUNX1T1. Issue 2 (9th February 2021)

• Record Type: Journal Article
• Authors: Hagiwara, Shinya; Kusumoto, Shigeru; Ito, Asahi; Masaki, Ayako; Shiraga, Kazuhide; Tachita, Takuto; Hirade, Kentaro; Oiwa, Kana; Suzuki, Tomotaka; Kinoshita, Shiori; Ri, Masaki; Ito, Yasuhiko; Komatsu, Hirokazu; Inagaki, Hiroshi; Iida, Shinsuke
• Is Part Of: EJHaem. Volume 2:Issue 2(2021)
• Page Start: 285
• Page End: 290
• Publication Date: 2021-02-09
• Subjects: allogeneic transplantation -- donor cell‐derived leukemia -- volunteer unrelated donor; Hematology -- Periodicals; 616.15
• DOI: 10.1002/jha2.169
• Languages: English
• ISSNs: 2688-6146

Abstract

Abstract: A 15‐year‐old male was diagnosed with acute myeloid leukemia with t(6;9)(p23;q34), a chimeric DEK ‐ NUP214 fusion gene. He underwent allogeneic bone marrow transplantation (allo‐BMT) from an unrelated volunteer donor at first molecular remission. Approximately 5 years after allo‐BMT, multiple bone marrow aspirations showed increased blasts to 63%, which were positive for myeloperoxidase, CD13, CD33, CD56, and CD34. Surprisingly, t(8;21)(q22;q22.1), a chimeric RUNX1‐RUNX1T1 (not DEK‐NUP214) fusion gene, was detected with full donor chimerism. To our best knowledge, this is the first case of a volunteer unrelated donor cell‐derived acute myeloid leukemia harboring a chimeric RUNX1‐RUNX1T1 fusion gene.