Restoring aged stem cell functionality: Current progress and future directions. (18th June 2020)

• Record Type: Journal Article
• Authors: Spehar, Kevin; Pan, Andrew; Beerman, Isabel
• Is Part Of: Stem cells. Volume 38:Number 9(2020)
• Page Start: 1060
• Page End: 1077
• Publication Date: 2020-06-18
• Subjects: adult stem cells -- aged stem cells -- aging -- hematopoietic stem cells -- interventions -- intestinal stem cells -- mesenchymal stem cells -- muscle stem cells -- neural stem cells -- rejuvenation -- skin stem cells -- stem cells; Cloning -- Periodicals; Clone cells -- Periodicals; Stem cells -- Periodicals; Cell Differentiation -- Periodicals; Cell Division -- Periodicals; Clone Cells -- Periodicals; Hematopoietic Stem Cells -- Periodicals; Stem Cells -- Periodicals; 571.84
• DOI: 10.1002/stem.3234
• Languages: English
• ISSNs: 1066-5099

Abstract

Abstract: Stem cell dysfunction is a hallmark of aging, associated with the decline of physical and cognitive abilities of humans and other mammals [ Cell 2013;153:1194]. Therefore, it has become an active area of research within the aging and stem cell fields, and various techniques have been employed to mitigate the decline of stem cell function both in vitro and in vivo. While some techniques developed in model organisms are not directly translatable to humans, others show promise in becoming clinically relevant to delay or even mitigate negative phenotypes associated with aging. This review focuses on diet, treatment, and small molecule interventions that provide evidence of functional improvement in at least one type of aged adult stem cell. Abstract : Possibly, combination of treatments may allow for more universal benefits encompassing many stem cell compartments.