Further understanding of epigenetic dysfunction of the retinal pigment epithelium in AMD. (3rd July 2020)

• Record Type: Journal Article
• Authors: Nashine, Sonali; Kenney, Maria Cristina
• Is Part Of: Expert review of ophthalmology. Volume 15:Number 4(2020)
• Page Start: 221
• Page End: 231
• Publication Date: 2020-07-03
• Subjects: AMD -- age-related macular degeneration -- epigenetics -- DNA methylation -- CPG methylation -- Epigenetics -- HDACs -- histone modifications -- microRNAs -- precision medicine for AMD; Ophthalmology -- Periodicals; 617.7005
• DOI: 10.1080/17469899.2020.1767597
• Languages: English
• ISSNs: 1746-9899

Abstract

ABSTRACT: Introduction: Modulation of epigenetic mechanisms that contribute to retinal development may render the eye susceptible to age-related macular degeneration (AMD). Progression of AMD involves alterations of epigenome such as CpG methylation and histone modifications, and study of the epigenetic regulation of molecular/cellular pathways associated with AMD might identify target epigenetic markers for treatment of AMD. Areas covered: In this review, we provide an overview of the influence of epigenetic factors on signaling pathways/related genes associated with AMD, mainly hypoxia, angiogenesis, inflammation, complement, and oxidative stress; and discuss the critical role of microRNAs in AMD. Expert opinion: Better understanding of epigenetic-mediated and microRNA-mediated regulation of the AMD disease-related pathways would help to assess the risk of developing AMD besides providing valuable insight on potential target candidates for AMD therapy.