Pregnancy immune tolerance at the maternal-fetal interface. (1st November 2020)

• Record Type: Journal Article
• Authors: Li, Xiaopeng; Zhou, Jiayi; Fang, Min; Yu, Bolan
• Is Part Of: International reviews of immunology. Volume 39:Number 6(2020)
• Page Start: 247
• Page End: 263
• Publication Date: 2020-11-01
• Subjects: BMI -- CD4+ T cells -- dNK cells -- HLA -- IDO -- macrophages -- miRNAs -- pregnancy; Immunology -- Periodicals; Autoimmune diseases -- Periodicals; 616.079
• DOI: 10.1080/08830185.2020.1777292
• Languages: English
• ISSNs: 0883-0185

Abstract

Abstract: Pregnancy is a natural process that poses an immunological challenge because non-self fetus must be accepted. During the pregnancy period, the fetus as 'allograft' inherits maternal and also paternal antigens. For successful and term pregnancy, the fetus is tolerated and nurtured enjoying immune privileges that minimize the risk of being rejected by maternal immune system. Multiple mechanisms contribute to tolerate the semi-allogeneic fetus. Here, we summarize the recent progresses on how the maternal immune system actively collaborates to maintain the immune balance and maternal-fetal tolerance.