64Cu-ATSM and 99mTc(CO)3-DCM20 potential in the early detection of rheumatoid arthritis. Issue 2 (4th March 2021)

• Record Type: Journal Article
• Authors: Dam, Trang Thuy; Hanaoka, Hirofumi; Nakajima, Takahito; Yamaguchi, Aiko; Okamura, Koichi; Chikuda, Hirotaka; Tsushima, Yoshito
• Is Part Of: Modern rheumatology. Volume 31:Issue 2(2021)
• Page Start: 350
• Page End: 356
• Publication Date: 2021-03-04
• Subjects: Early detection -- hypoxia -- macrophage mannose receptor -- molecular imaging -- rheumatoid arthritis; Rheumatology -- Periodicals; 616.723005
• DOI: 10.1080/14397595.2020.1751945
• Languages: English
• ISSNs: 1439-7595

Abstract

Abstract: Objectives: Molecular imaging constitutes a promising technique for the early detection of rheumatoid arthritis (RA). Macrophages and hypoxia play significant roles in inflamed synovium. In the present study, we evaluated the efficacy of radiopharmaceuticals that target macrophage mannose receptors ( 99m Tc-labeled mannosylated dextran or 99m Tc(CO)3 -DCM20) and hypoxia (copper(II) diacetyl-di(N 4 -methylthiosemicarbazone) or Cu-ATSM) for the early detection of RA in collagen-induced arthritis (CIA) mice models. Methods: CIA model was developed in DBA/1 mice, and the clinical score for arthritis was visually assessed on a regular basis. Two biodistribution studies were performed in a paired-labeled format using 2-deoxy-2- 18 F-fluoro-D-glucose ( 18 F-FDG) as a reference: (1) 99m Tc(CO)3 -DCM20 with 18 F-FDG and (2) 67 Cu-ATSM with 18 F-FDG. Results: The accumulation levels of 99m Tc(CO)3 -DCM20 and 67 Cu-ATSM in forepaws, hindpaws, and knee joints of CIA mice were significantly higher than that of control mice. In contrast, 18 F-FDG uptake in hindpaws and knee joints showed no significant difference between CIA and control mice. The radioactivity levels of 99m Tc(CO)3 -DCM20 and 67 Cu-ATSM were significantly correlated with the clinical scores for the paws. Conclusion: These results suggest the potential usefulness of 99m Tc(CO)3 -DCM20 and radiolabeled Cu-ATSM for the imaging and early detection of RA.