Elevated soluble Tim-3 correlates with disease activity of systemic lupus erythematosus. (17th February 2021)

• Record Type: Journal Article
• Authors: Zhao, Di; Li, Chunhao; Yang, Xiao; Yan, Wenjiang; Zhang, Yi
• Is Part Of: Autoimmunity. Volume 54:Number 2(2021)
• Page Start: 97
• Page End: 103
• Publication Date: 2021-02-17
• Subjects: sTim-3 -- disease activity -- systemic lupus erythematosus; Autoimmunity -- Periodicals; Autoimmune diseases -- Periodicals; 571.973
• DOI: 10.1080/08916934.2021.1891535
• Languages: English
• ISSNs: 0891-6934

Abstract

Abstract: T cell immunoglobulin and mucin domain-containing molecule-3(Tim-3) has been found to play important roles in systemic lupus erythematosus (SLE), but whether sTim-3 is involved in the development of SLE remains unknown. In this study, we firstly observed an increased expression of plasma sTim-3 in SLE patients, especially active SLE patients. The plasma sTim-3 levels were positively correlated with anti-dsDNA, SLEDAI score, ESR, and urine albumin. The plasma sTim-3 levels were negatively correlated with C3 and C4. The area under the ROC curve (AUC) values indicated that the plasma sTim-3 level was significantly discriminative of early active SLE from stable SLE and HC with high sensitivity and specificity. The present results suggest that sTim-3 might serve as a potential biomarker for promising the disease activity of SLE.