Cell-laden alginate hydrogels for the treatment of diabetes. (2nd August 2020)

• Record Type: Journal Article
• Authors: Izeia, Lukin; Eufrasio-da-Silva, Tatiane; Dolatshahi-Pirouz, Alireza; Ostrovidov, Serge; Paolone, Giovanna; Peppas, Nicholas A.; De Vos, Paul; Emerich, Dwaine; Orive, Gorka
• Is Part Of: Expert opinion on drug delivery. Volume 17:Number 8(2020)
• Page Start: 1113
• Page End: 1118
• Publication Date: 2020-08-02
• Subjects: Diabetes mellitus -- cell encapsulation -- cell-laden hydrogels -- alginate -- drug delivery; Drug delivery devices -- Periodicals; Drug delivery systems -- Periodicals; 615.605
• DOI: 10.1080/17425247.2020.1778667
• Languages: English
• ISSNs: 1742-5247

Abstract

ABSTRACT: Introduction: Diabetes mellitus is an ever-increasing medical condition that currently suffers 1 of 11 adults who may have lifelong commitment with insulin injections. Cell-laden hydrogels releasing insulin may provide the ultimate means of correcting diabetes. Here, we provide insights of this cell-based approach including latest preclinical and clinical progress both from academia and industry. Area covered: The present article focuses on reviewing latest advances in cell-laden hydrogels both from the technological and biological perspective. The most relevant clinical results including clinical trials are also discussed. Expert opinion: Current progress in technological issues (stem cells, devices, biomaterials) have contributed cell encapsulation science to have a very relevant progress in the field of diabetes treatment.