Assessing mental health in children and adolescent with MTHFR polymorphisms: psychiatric disorders, executive functioning, and symptom profile in a Turkish clinical sample. Issue 2 (3rd April 2021)

• Record Type: Journal Article
• Authors: Poyraz Fındık, Onur Tuğçe; Murat, Duygu; Gümüştaş, Funda; Rodopman Arman, Ayşe; Özer, Işıl
• Is Part Of: Children's health care. Volume 50:Issue 2(2021)
• Page Start: 220
• Page End: 237
• Publication Date: 2021-04-03
• Subjects: Methylenetetrahydrofolate reductase (NADPH2) -- genetics -- mental health -- attention-deficit hyperactivity disorder -- executive function; Children -- Hospital care -- Periodicals; Child health services -- Periodicals; Children -- Preparation for medical care -- Periodicals; 362.19892
• DOI: 10.1080/02739615.2021.1871616
• Languages: English
• ISSNs: 0273-9615

Abstract

ABSTRACT: This study investigated behavioral phenotype, executive functions profile, and the existence of comorbid psychiatric disorders in children and adolescents with methylenetetrahydrofolate reductase (MTHFR) polymorphisms admitted to pediatric metabolism outpatient clinic. Internalizing problems, especially somatic complaints were common in patients with MTHFR. More than half of the cases had emotional control and initiating problems as executive function deficits. Attention-deficit/hyperactivity disorder was the most common psychiatric diagnosis, followed by anxiety disorder. Current findings emphasize that health care providers should be aware of the mental health needs of cases with MTHFR polymorphism in order to make plans of integrative physical and mental health care.