Outcomes for allogeneic stem cell transplantation in refractory mycosis fungoides and primary cutaneous gamma Delta T cell lymphomas. Issue 12 (14th October 2020)

• Record Type: Journal Article
• Authors: Isufi, Iris; Seropian, Stuart; Gowda, Lohith; Wilson, Lynn D.; Roberts, Kenneth; Girardi, Michael; Perreault, Sarah; Foss, Francine
• Is Part Of: Leukemia & lymphoma. Volume 61:Issue 12(2020)
• Page Start: 2955
• Page End: 2961
• Publication Date: 2020-10-14
• Subjects: Mycosis fungoides -- Sézary syndrome -- primary cutaneous gamma delta t cell lymphoma -- allogeneic stem cell transplant -- reduced intensity transplantation; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2020.1790555
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: We report results on 23 patients with cutaneous T cell lymphoma (7 primary cutaneous γδ T cell lymphoma [PCGDT], 16 mycosis fungoides/Sézary syndrome [MF/SS]) who underwent allogeneic stem cell transplantation. All pts had skin involvement, 14 had total skin electron beam before conditioning. Donors were 10/10 HLA matched related (13), 5/10 haploidentical (4), and matched unrelated (5) or mismatched unrelated (1). Thirteen were in a clinical complete remission at the time of transplant. The 100-day transplant related mortality for the MF/SS and PCGDT patients was 12% and 29%, respectively. At a median follow up of 5.5 years, the overall survival and disease-free survival for MF/SS patients was 75% and 64%, respectively, and 6 of 10 MF/SS pts in long term complete response had a partial response at the time of transplant. Of seven PCGDT patients, four of seven are alive at a median follow up of 5 years and three are disease-free.