The feasibility of clinical evaluation for anterior uveitis through spectral‐domain optical coherence tomography in dogs. (18th November 2021)

• Record Type: Journal Article
• Authors: Jeong, Youngseok; Kang, Seonmi; Shim, Jaeho; Lee, Eunji; Jeong, Dajeong; Park, Sanghyun; Lee, Songhui; Kim, Su An; Seo, Kangmoon
• Is Part Of: Veterinary ophthalmology. Volume 25(2022)Supplement 1
• Page Start: 111
• Page End: 121
• Publication Date: 2021-11-18
• Subjects: anterior uveitis -- ARI index -- cell -- central corneal thickness -- dog -- SD‐OCT; Veterinary ophthalmology -- Periodicals; 636.08977
• DOI: 10.1111/vop.12955
• Languages: English
• ISSNs: 1463-5216

Abstract

Abstract: Objective: To evaluate the clinical application of spectral‐domain optical coherence tomography (SD‐OCT) for anterior uveitis in dogs. Animals and procedures: Client‐owned dogs presenting with anterior uveitis and clinically healthy dogs were enrolled in this study. Included eyes were divided into 5 groups by flare grade and 3 groups by cell grade through slit‐lamp biomicroscopy. Each eye was examined using SD‐OCT following slit‐lamp biomicroscopy. The ratio of aqueous signal intensity to air signal intensity, which is called the aqueous‐to‐air relative intensity (ARI) index, was used to evaluate the flare grade. Cell number, central corneal thickness (CCT), and the presence of keratic precipitates (KPs) were analyzed on SD‐OCT. The OCT parameters, including ARI index, cell number, and CCT, were compared to the slit‐lamp clinical flare and cell grade. Results: Thirty‐six eyes with anterior uveitis and 27 healthy eyes were enrolled. The ARI index showed a significant correlation with clinical flare grade ( r s = 0.811, p < .001). In multiple regression analysis, the ARI index and CCT showed a significant negative correlation ( r = −0.258, p = .044). The number of cells on SD‐OCT significantly increased with cell grade on slit‐lamp biomicroscopy ( r s = 0.653, p < .001). The clinical flare grade and CCT were significantly correlated in the partial correlation analysis after controlling for age (partial correlation coefficient = 0.471, p = .002). KPs were observed in 61% of the eyes with flare using SD‐OCT (22/36 eyes). Conclusions: Spectral‐domain optical coherence tomography could provide quantitative information, including the ARI index, cell counts, and CCT in dogs. SD‐OCT is an auxiliary modality for slit‐lamp biomicroscopy when evaluating anterior uveitis in dogs.