Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma. Issue 5 (29th October 2019)

• Record Type: Journal Article
• Authors: Rahmani, Farzad; Ziaeemehr, Aghigh; Shahidsales, Soodabeh; Gharib, Masoumeh; Khazaei, Majid; Ferns, Gordon A.; Ryzhikov, Mikhail; Avan, Amir; Hassanian, Seyed M.
• Is Part Of: Journal of cellular physiology. Volume 235:Issue 5(2020:May)
• Page Start: 4146
• Page End: 4152
• Publication Date: 2019-10-29
• Subjects: hepatocellular carcinoma -- microRNA -- PI3K/AKT/mTOR pathway; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.29333
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Hepatocellular carcinoma (HCC) is one of the common malignant human tumors with high morbidity worldwide. Aberrant activation of the oncogenic phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling is related to clinicopathological features of HCC. Emerging data revealed that microRNAs (miRNAs) have prominent implications for regulating cellular proliferation, differentiation, apoptosis, and metabolism through targeting the PI3K/AKT/mTOR signaling axis. The recognition of the crucial role of miRNAs in hepatocarcinogenesis represents a promising area to identify novel anticancer therapeutics for HCC. The present study summarizes the major findings about the regulatory role of miRNAs in the PI3K/AKT/mTOR pathway in the pathogenesis of HCC. Abstract : Emerging data revealed that microRNAs (miRNAs) have prominent implications for regulating cellular proliferation, differentiation, apoptosis, and metabolism through targeting the phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling axis. The present study summarizes the major findings about the regulatory role of miRNAs in PI3K/AKT/mTOR pathway in the pathogenesis of hepatocellular carcinoma.