Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer. (31st December 2022)

• Record Type: Journal Article
• Authors: Zhao, Jing; Lu, Huidan; Xu, Danxia; Sun, Ruiqi; Fang, Chengyu; Zhao, Qiyu; He, Chang; Pan, Yuwei; Xu, Feng; Jiang, Tianna
• Is Part Of: International journal of hyperthermia. Volume 39:Number 1(2022)
• Page Start: 1026
• Page End: 1035
• Publication Date: 2022-12-31
• Subjects: Pancreatic cancer -- nanosecond pulsed electric field -- combination cancer therapy -- neutrophils; Thermotherapy -- Periodicals; 615.832
• DOI: 10.1080/02656736.2022.2093994
• Languages: English
• ISSNs: 0265-6736

Abstract

Abstract: Objective: Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide. Poor prognosis and low survival rates have driven the development of novel therapeutic strategies. Nanosecond pulsed electric field has emerged as a novel, minimal invasive and non-thermal treatment for solid tumors. It is of great significance to study the combination therapy of nsPEF and other treatment strategies for pancreatic cancer. Methods: We developed neutrophil membrane-wrapped liposomal nanoparticles loaded with gemcitabine (NE/Lip-GEM) and investigated their use as a complementary agent for nsPEF treatment. Results: Our results showed that neutrophil-mediated delivery of liposomal-gemcitabine (NE/Lip-GEM) efficiently inhibited the growth of pancreatic tumors in mice whose has been treated with incomplete nsPEF ablation. Conclusions: The combination of nsPEF and NE/Lip-GEM may be a promising synergistic strategy for pancreatic cancer therapy.