Three novel furospirostanol glycosides and a steroidal alkaloid glycoside from the bulbs of Fritillaria camtschatcensis (L.) Ker Gawl., and their cytotoxicity. Issue 15 (1st August 2022)

• Record Type: Journal Article
• Authors: Iguchi, Tomoki; Kuroda, Minpei; Takayama, Hiroshi; Mimaki, Yoshihiro
• Is Part Of: Natural product research. Volume 36:Issue 15(2022)
• Page Start: 3917
• Page End: 3923
• Publication Date: 2022-08-01
• Subjects: Fritillaria camtschatcensis -- Liliaceae -- bulb -- furospirostanol glycoside -- steroidal alkaloid -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1897590
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three novel steroidal glycosides (1 –3 ) and a previously described steroidal alkaloid glycoside (4 ) have been isolated from the bulbs of Fritillaria camtschatcensis (L.) Ker Gawl. (Liliaceae). The structures of novel compounds 1 –3 were characterized based on NMR spectroscopy and chemical transformations. Compounds 1 –3 are furospirostanol glycosides bearing a (3 S )-3-hydroxy-3-methylglutaryl moiety at C-26 in the aglycone. Compounds 1 –4 were evaluated in terms of their cytotoxic activities toward HL-60 human promyelocytic leukemia cells, A549 human lung adenocarcinoma cells, and SBC-3 human lung small cell carcinoma cells. Only 4 showed moderate cytotoxicity against HL-60, A549, and SBC-3 cells with IC50 values of 22.9, 13.3, and 11.9 µM, respectively. Compound 4 was found to cause necrotic-like cell death in HL-60 cells. Graphical Abstract: UF0001