Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100. (9th September 2015)

• Record Type: Journal Article
• Authors: Toledano, Víctor; Hernández-Jiménez, Enrique; Cubillos-Zapata, Carolina; Flandez, Marta; Álvarez, Enrique; Varela-Serrano, Aníbal; Cantero, Ramón; Valles, Gema; García-Rio, Francisco; López-Collazo, Eduardo
• Other Names: Agrawal Anshu Academic Editor.
• Is Part Of: Mediators of inflammation. Volume 2015(2015)
• Publication Date: 2015-09-09
• Subjects: Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1155/2015/942517
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : We show that galactomannan, a polysaccharide consisting of a mannose backbone with galactose side groups present on the cell wall of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor. The nuclear factor kappa-light-chain-enhancer of activated B cells 2 (NF κ B2)/p100 was overexpressed after galactomannan challenge. Knocking down NF κ B2/p100 using small interfering RNA (siRNA) indicated that NF κ B2/p100 expression is a crucial factor in the progression of the galactomannan-induced refractoriness. The data presented in this study could be used as a modulator of inflammatory response in clinical situations where refractory state is required.