Two new triterpenoids from the leaves of Cyclocarya paliurus (Batalin) Iljinskaja. Issue 15 (1st August 2022)

• Record Type: Journal Article
• Authors: Liu, Yao; Zheng, Guan-Tao; Zhang, Xuan-Xuan; Zhang, Xian-Tao; Shang, Xu-Lan; Fang, Sheng-Zuo; Zhang, Jian; Yin, Zhi-Qi
• Is Part Of: Natural product research. Volume 36:Issue 15(2022)
• Page Start: 3938
• Page End: 3944
• Publication Date: 2022-08-01
• Subjects: Cyclocarya paliurus -- triterpenoids -- flavonoids -- fibrosis -- fibronectin -- HK-2 cells; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1900845
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two previously undescribed triterpenoids (1–2 ), along with thirteen known compounds (3–15 ) were isolated from a CHCl3 -soluble extract of the leaves of Cyclocarya paliurus . Their structures were established on the basis of chemical and spectroscopic approaches. These compounds were assessed for their therapeutic effects on diabetic nephropathy (DN)-evoked fibrosis through High-Glucose and transforming growth factor-β1 (TGF-β1) challenged HK-2 cells. Among them, compounds 3, 5 and 8 could remarkedly decrease the level of fibronectin to relieve DN with 27.66 ± 2.77%, 6.09 ± 0.57% and 17.74 ± 5.83% inhibition rate at 10 μM, 10 μM and 1 μM, respectively. Graphical Abstract: UF0001