The association between visceral adiposity with systemic inflammation, oxidative stress, and risk of post-surgical adhesion. (4th July 2022)

• Record Type: Journal Article
• Authors: Arjmand, Mohammad-Hassan
• Is Part Of: Archives of physiology and biochemistry. Volume 128:Number 4(2022)
• Page Start: 869
• Page End: 874
• Publication Date: 2022-07-04
• Subjects: Post-surgical abdominal adhesion -- visceral fat -- obesity -- inflammation -- fibrotic molecules; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2020.1733617
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Abdominal and pelvic adhesions are common post-operative complications. Despite new medical technologies, these adhesions are appearing to be unavoidable and little is known about their causation; for example, why certain patients/or tissues are more prone to adhesions. There have been no clinical studies about increasing the risk adhesions in obese patients, but there is some evidence about the molecular mechanisms involving visceral fat (VF) that may lead to profibrotic conditions. VF is an endocrine/inflammatory organ which produces many biologically active molecules such as adipokines and inflammatory cytokines. Inflammatory conditions, oxidative stress, and the expression some fibrotic molecules in the VF may induce pathological conditions in the abdominal cavity that predispose to the formation of fibrotic bands.