Highly oxygenated ent-atisane and podocarpane diterpenoids from Excoecaria agallocha. Issue 15 (1st August 2022)

• Record Type: Journal Article
• Authors: Liu, Guangyan; Zhang, Zhisen; Wang, Yuanhao; Li, Xuewen
• Is Part Of: Natural product research. Volume 36:Issue 15(2022)
• Page Start: 3924
• Page End: 3930
• Publication Date: 2022-08-01
• Subjects: Excoecaria agallocha -- ent-atisane diterpenoid -- podocarpane diterpenoid -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1900177
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new highly oxygenated ent -atisane diterpenoid, namely excagallonoid A (1 ), together with five known analogues (2 − 6 ) were isolated from the leaves and twigs of Excoecaria agallocha . Their structures were elucidated on the basis of extensive spectroscopic analyses (HRESIMS, UV, IR, 1 D and 2 D NMR), and the absolute configurations of 1 and 5 were determined by single-crystal X-ray diffraction. Compound 1 represents the first example of an ent -atisane diterpenoid featuring a vicinal 2, 3-diol moiety. Compounds 1 and 4 exhibited weak cytotoxicities in vitro against RKO colon cancer cells with IC50 values of 28.7 ± 1.98 and 32.6 ± 2.81 µM, respectively. Graphical Abstract: UF0001