Stimulating effects of vardenafil, tadalafil, and udenafil on vascular endothelial growth factor, angiogenesis, vitamin D3, bone morphogenic proteins in ovariectomized rats. (4th July 2022)

• Record Type: Journal Article
• Authors: Huyut, Zübeyir; Alp, Hamit Hakan; Bakan, Nuri; Yıldırım, Serkan; Şekeroğlu, Mehmet Ramazan
• Is Part Of: Archives of physiology and biochemistry. Volume 128:Number 4(2022)
• Page Start: 1121
• Page End: 1127
• Publication Date: 2022-07-04
• Subjects: Angiogenesis -- phosphodiesterase-5 inhibitor -- ovariectomy -- bone morphogenetic protein -- vitamin D; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2020.1755695
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Objective: This study investigated the effect of vardenafil, tadalafil, and udenafil from phosphodiesterase-5 inhibitors (PDE-5Is) on bone morphogenic-protein (BMP)2 and 4 levels, along with angiogenesis in ovariectomized rat's kidney. Method: Rats were randomly divided into five groups ( n = 10). Sham: abdomen was opened, and closed. OVX: ovaries were removed. OVX + vardenafil, OVX + tadalafil, and OVX + udenafil groups: ovaries were removed and closed, and after 6 months from postoperative, 10 mg/kg of vardenafil, tadalafil, and udenafil were administrated as daily a single-dose for 60 days, respectively. Histopathologic and immunohistochemical examinations were performed for angiogenesis, and biochemical analysis for vascular endothelial growth-factor (VEGF), VitaminD3, BMP2 and 4 levels in rat's kidney. Results: VEGF, BMP2 and 4, VitaminD3, and angiogenesis were high in the all inhibitor groups compared with the sham and OVX ( p < .05). However, BMP4 levels were only high in the OVX + tadalafil group ( p < .05). Conclusion: The results indicated that vardenafil, udenafil, and especially tadalafil increased VEGF, BMP2, and VitaminD3 levels.