Usneaceratins A and B, two new secondary metabolites from the lichen Usnea ceratina. Issue 15 (1st August 2022)

• Record Type: Journal Article
• Authors: Bui, Van Muoi; Huynh, Bui Linh Chi; Pham, Nguyen Kim Tuyen; Nguyen, Thi Anh Tuyet; Nguyen, Thi Thuy Trang; Nguyen, Kim Phi Phung; Nguyen, Tan Phat
• Is Part Of: Natural product research. Volume 36:Issue 15(2022)
• Page Start: 3945
• Page End: 3950
• Publication Date: 2022-08-01
• Subjects: Usnea ceratina -- usneaceratin -- dibenzofuran -- phenolic -- α-glucosidase inhibitory activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1901288
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new compounds, comprising one dibenzofuran, named usneaceratin A (1 ), and one phenolic acid, named usneaceratin B (2 ), together with one known dibenzofuran, isousnic acid (3 ), and two known phenolics, orsellinic acid (4 ) and methyl orsellinate (5 ) were clarified from the lichen Usnea ceratina using variously chromatographic methods. Their structures were testified by comprehensive HR-ESI-MS, and NMR spectroscopic analysis, and comparison with published data. Their α -glucosidase inhibitory activity of all compounds was measured. Usneaceratin B (2 ) possessed better inhibition against α -glucosidase enzyme (IC50 value of 41.8 μM) than the standard drug acarbose (IC50 value of 214.50 μM). Graphical Abstract: UF0001